| Date | Opponent/Score | Top VT Scorers | Top VT Rebounders |
| Thu,11/10/05 WIN | VT 80, Radford 50 NABC Classic Record: 1-0 (0-0 ACC) | Collins 17 Dowdell 16 | Gordon 8 Washington 6 |
| Sat,11/12/05 Loss | Bowling Green 72, VT 71 NABC Classic Record: 1-1 (0-0 ACC) | Collins 22 Washington 17 | Collins 8 Gordon 5 |
| Sun,11/13/05 WIN | VT 54, W. Carolina 40 NABC Classic Record: 2-1 (0-0 ACC) | Gordon 11 Dowdell 10 Washington 10 | Gordon 10 Three with 4 |
| Fri,11/18/05 WIN | VT 74, Mt. St. Mary's 62 Record: 3-1 (0-0 ACC) | Washington 24 Dowdell 18 | Washington 10 Diakite 7 |
| Mon,11/21/05 WIN | VT 71, Marshall 54 Record: 4-1 (0-0 ACC) | Washington 17 Dowdell 16 | Washington 6 Diakite 5 |
| Fri,11/25/05 WIN | VT 77, Morgan State 49 Record: 5-1 (0-0 ACC) | Washington 16 Collins 14 | Collins 14 Gordon 5 |
| Mon,11/28/05 Loss | Ohio State 69, VT 56 Record: 5-2 (0-0 ACC) | Dowdell 15 Collins 14 | Collins 14 Washington 4 |
| Sun,12/4/05 Loss | #1 Duke 77, VT 75 Record: 5-3 (0-1 ACC) | Collins 25 Dowdell 15 | Collins 8 Washington 6 |
| Wed,12/7/05 WIN | VT 94, NC A&T 66 Record: 6-3 (0-1 ACC) | Dowdell 25 Collins 17 | Collins 14 Gordon 7 |
| Sat,12/10/05 WIN | VT 73, St. John's 64 Record: 7-3 (0-1 ACC) | Collins 21 Dowdell 18 | Dowdell 4 |
| Sun,12/18/05 WIN | VT 59, Stanford 52 Record: 8-3 (0-1 ACC) | Collins 16 Gordon 12 | Collins 12 Washington 8 |
| Tue,12/27/05 WIN | VT 74, William & Mary 64 Record: 9-3 (0-1 ACC) | Collins 21 Dowdell 18 | Collins 11 Gordon 8 |
| Fri,12/30/05 Loss | Old Dominion 58, VT 55 Record: 9-4 (0-1 ACC) | Dowdell 18 Gordon 18 | Washington 11 Collins 7 Gordon 7 |
| Mon,1/2/06 WIN | VT 77, James Madison 58 Record: 10-4 (0-1 ACC) | Collins 32 Washington 19 | Gordon 7 Collins 6 |
| Sat,1/7/06 Loss | FSU 74, VT 68 Record: 10-5 (0-2 ACC) | Witherspoon 19 Dowdell 18 | Gordon 5 Dowdell 5 |
| Tue,1/10/06 Loss | #20 UNC 64, VT 61 Record: 10-6 (0-3 ACC) | Witherspoon 17 Dowdell 13 | Gordon 6 Washington 5 |
| Sun,1/15/06 Loss | Virginia 54, VT 49 Record: 10-7 (0-4 ACC) | Dowdell 16 Collins 14 | Washington 5 Collins 5 Dowdell 5 |
| Sat,1/21/06 Loss | Maryland 81, VT 72 Record: 10-8 (0-5 ACC) | Dowdell 21 Collins 18 | Washington 7 Collins 6 |
| Thu,1/26/06 Loss | #2 Duke 80, VT 67 Record: 10-9 (0-6 ACC) | Dowdell 21 Collins 13 | Collins 10 Gordon 8 |
| Sat,1/28/06 WIN | VT 76, Wake Forest 70 Record: 11-9 (1-6 ACC) | Vassallo 29 Gordon 21 | Gordon 14 Vassallo 10 |
| Tue,1/31/06 WIN | VT 63, Georgia Tech 62 Record: 12-9 (2-6 ACC) | Washington 21 Dowdell 15 | Washington 6 Gordon 6 Vassallo 6 |
| Sat,2/4/06 Loss | #15 BC 74, VT 73 Record: 12-10 (2-7 ACC) | Dowdell 20 Vassallo 14 Gordon 14 | Collins 7 Gordon 6 |
| Wed,2/8/06 WIN | VT 75, Clemson 74 (OT) Record: 13-10 (3-7 ACC) | Gordon 21 Dowdell 19 | Gordon 16 Washington 4 Collins 4 |
| Sat,2/11/06 Loss | Virginia 81, VT 77 (OT) Record: 13-11 (3-8 ACC) | Gordon 24 Vassallo 19 | Gordon 7 Dowdell 7 |
| Sat,2/18/06 Loss | #21 N.C. State 70, VT 64 Record: 13-12 (3-9 ACC) | Collins 15 Gordon 11 | Collins 11 Vassallo 6 |
| Wed,2/22/06 Loss | Miami 70, VT 59 Record: 13-13 (3-10 ACC) | Dowdell 15 Vassallo 15 | Dowdell 6 Collins 5 |
| Sat,2/25/06 WIN | VT 72, FSU 61 Record: 14-13 (4-10 ACC) | Dowdell 20 Gordon 15 | Washington 9 Dowdell 5 |
| Wed,3/1/06 Loss | Clemson 86, VT 81 Record: 14-14 (4-11 ACC) | Dowdell 17 Collins 16 | Collins 9 Gordon 5 Washington 5 |
| Sat,3/4/06 Loss | #12 BC 59, VT 57 Record: 14-15 (4-12 ACC) | Gordon 21 Dowdell 13 | Gordon 9 |
| Thu,3/9/06 Loss | Virginia 60, VT 56 ACC Tournament Record: 14-16 | Dowdell 15 Sean Harris 12 | Sailes 8 Washington 5 |
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