The Big 10 has 8 of its 14 members in the Eastern Time Zone,
so time-wise, those 3 eastern schools shouldn't feel that isolated. Culturally, those 3 may feel isolated, but I feel the same way about BC, Syracuse, Pitt, Notre Dame, and Louisville. Of all the non-charter ACC schools, only Virginia Tech, Florida State, and Georgia Tech feel natural. Culturally, Miami isn't a natural fight but they are in the state of Florida with rival FSU.